A significant amount of the newest science and research attempting to tackle America’s growing obesity problem is focused on hormonal disruptions and imbalances such as leptin resistance. LepToThin™ is natural science’s newest answer, in supplement form, to help address this issue. LepToThin™ contains LeptiPro™ which is the primary active ingredient to assist in improving leptin signaling. The main mechanism of action of this supplement occurs by inhibiting protein tyrosine phosphatase 1B, commonly known as (PTP1B). A plethora of research is currently being performed to assess the efficacy of PTP1B in the treatment of obesity, insulin resistance and leptin resistance.

To help your understanding of this ever-important concept and physiological cascade of events, I’ll provide a number of credible research excerpts followed by my ‘fourth grade version’ and interpretation. This should help you get to the bottom line on how and why this can significantly help you in your quest to lose weight naturally and improve your health.

Deal? Here we go…

The science says: In June of 2009, the medical journal, Molecular and Cellular Biology stated that:  neuronal PTP1B inhibition results in decreased hypothalamic AMPK activity, isoform-specific AMPK activation in peripheral tissues and downstream gene expression changes that promote leanness and increased energy expenditure. Therefore, the mechanism by which PTP1B regulates adiposity and leptin sensitivity is likely to involve coordinated regulation of AMPK in hypothalamus and peripheral tissues.

The interpretation: Inhibiting PTP1B may actually have an effect on the brain that would help you improve body composition and burn fat.

The science says: PTP1B Inhibitors:  (PTP1B) is a highly validated molecular target, which mediates insulin resistance in mammals. PTP1B dephosphorylates the insulin receptor (IR) thus blunting its ability to transduce signal upon insulin binding. Inhibitors of PTP1B would be expected to restore activity to the IR and thus would find therapeutic benefit in the treatment of diabetes.

The interpretation: Discovering and manufacturing PTP1B inhibitors are currently one of the ‘hot topics’ in the pharmacological approach to to finding a drug to address the obesity problem, which is a primary contributing factor to type 2 diabetes.

The science says: Protein tyrosine phosphatase 1B (PTP1B) contributes to leptin resistance by inhibiting intracellular leptin receptor signaling. Hypothalamic PTP1B is specifically increased during HF diet-induced leptin resistance. This increase in PTP1B is due in part to chronic hyperleptinemia, suggesting that hyperleptinemia is one mechanism contributing to the development of leptin resistance.

The interpretation: When mice are fed a high fat diet it can increase the amount of PTP1B in the brain. A high fat diet possibly induced an overabundance of circulating leptin which leaves more leptin in the blood. The body then may become resistance to leptin’s effects; two of which are  regulating appetite and burning fat.

The science says: Neuronal PTP1B regulates adiposity, body weight and leptin action.

The interpretation: PTP1B has a big say in whether you store excess fat, how much you weigh and it also plays a pivotal role in the function of one of your master metabolic hormones-leptin.

The science says: PTP1B is expressed in hypothalamic regions harboring leptin-responsive neurons. PTP1B regulates leptin signaling in vivo, likely by targeting Jak2. Mice lacking the protein-tyrosine phosphatase PTP1B are hypersensitive to insulin and resistant to obesity. PTP1B may be a novel target to treat leptin resistance in obesity.

The interpretation: PTP1B is present within the brain and effects the way that leptin is able to effect the brain. Mice that were devoid of PTP1B were literally resistant to obesity. One could extrapolate that with either the absence or decreased over-expression of PTP1B, leptin and insulin would both work more efficiently to regulate weight and metabolism. This study showed that PTP1B does in fact regulate leptin signaling.

The science says: Protein tyrosine phosphatase 1B (PTP1B) is a key negative regulator of signaling by both of these hormones, so that inhibitors of this enzyme may provide promise for correcting endocrine abnormalities in both diabetes and obesity. As with other tyrosine phosphatases, identification of viable drug candidates targeting PTP1B has been elusive because of the nature of its active site. Beginning with novel phosphotyrosine mimetics, we have designed some of the most potent PTP1B inhibitors. However, their highly acidic structures limit intrinsic permeability and pharmacokinetics.

The interpretation: “We wish we could find something that inhibits PTP1B without so many side effects because if we could, we would make billions.”

As far back as 2002 analysts have estimated that an effective and safe drug targeting obesity could generate as much as $26 billion per year in the USA alone. “It is probably the largest pharmaceutical market ever, and carries with it 27–30 dangerous co-morbidities,” said Louis Tartaglia, vice president of metabolic diseases at Millennium Pharmaceuticals. If you add the patients who are obese and diabetic, the number soars even higher, as obesity and diabetes are linked diseases. (Some research says that as much as 80% of type 2 diabetes is related to obesity.

The science says: Published studies demonstrate that the botanically derived phytochemical, isolated and purified single-peak Isoquinoline Alkaloid Berberine HCl, specifically and potently inhibits human Protein Tyrosine Phosphates 1B (PTP1 B).

The interpretation: LepToThin™ with LeptoPro™ was formulated to specifically and naturally improve the body’s ability to respond to leptin signaling, thus helping you become better able to lose weight.

References:

LepToThin review

Am J Physiol Endocrinol Metab 296: E291-E299, 2009

Nature Medicine – 12, 917 – 924 (2006)

Dev Cell. 2002 Apr;2(4):385-7.

Well, for the record, the scientifically accurate answer is…compositionally, LeptiPro™ is a purified API-grade Berberine in the stable HCl form, conjugated and complexed with a proprietary Long-Chain Fatty Acid matrix for enhanced uptake and transport across the blood-brain-barrier.

Whew! Now here’s the good part….

There is mounting evidence that the clinical efficacy of purified API-grade Berberine shows potent and specific inhibition of PTP1B, among other important mechanisms dealing  with weight loss, weight control, and the hormones that influence those functions.

In layman’s terms…it just may be science’s newest answer to your weight loss prayers!

LepToThin™ is the first product available to include the powerful natural compound LeptiPro™.  And if you have been unable to lose weight, this might just be your “knight in shining armor!”

What is exciting is that LeptiPro was developed as a natural and efficacious way to help modulate weight via multiple mechanisms, meaning it works on a variety of physiological pathways– including, but not limited to:

1) The enhancement of leptin sensitivity (primarily via potent and specific inhibition of Protein Tyrosine Phosphatase 1B — PTP1B). Over ten years of science is now pointing to the fact that this may be a key factor in the chronically overweight and obese.

2) The enhancement of insulin sensitivity (via multiple mechanisms, including up-regulation of AMP-activated Protein Kinase (AMPK), up-regulation of AMP/ATP ratios, down-regulation of Interleukin-6 (IL-6), inhibition of alpha-Glucoside, and inhibition of PTB1B. (Insulin and leptin work hand-in-hand.)

3) The down-regulation of lipogenesis and up-regulation of energy expenditure in adipose tissue, decreasing fat production and fat storage and increasing fat burning.

4) The down-regulation of adipogenic enzymes and transcription factors.

What does this mean for you? Well, for most people it is THE scientific breakthrough you’ve been waiting for in terms of breaking through stubborn barriers that have kept you from losing weight in the past.

You see, LeptiPro™ helps your body conquer the two ‘villains’ of weight management…cravings and fat storage.

And because LeptiPro is  shown to have powerful positive effects on balancing the hormone that controls those two ‘villains,’ most people experience unprecedented weight loss because these problems have never been effectively addressed.

LepToThin’s  proprietary matrix capitalizes on these powerful mechanisms and adds to it the potent fat burning and anti-inflammatory effects of EGCG’s in our green tea extract. Also included is a patented  form of  chromium, which is shown to have blood sugar balancing properties. Added with this is energy enhancing panax ginseng. To top it all off…a promising new ‘superfood’ from the sea, known as fucoxanthin, may potentially work very well in assisting you with losing weight.

For more information about LepToThin go here.  LepToThin review.