A significant amount of the newest science and research attempting to tackle America’s growing obesity problem is focused on hormonal disruptions and imbalances such as leptin resistance. LepToThin™ is natural science’s newest answer, in supplement form, to help address this issue. LepToThin™ contains LeptiPro™ which is the primary active ingredient to assist in improving leptin signaling. The main mechanism of action of this supplement occurs by inhibiting protein tyrosine phosphatase 1B, commonly known as (PTP1B). A plethora of research is currently being performed to assess the efficacy of PTP1B in the treatment of obesity, insulin resistance and leptin resistance.

To help your understanding of this ever-important concept and physiological cascade of events, I’ll provide a number of credible research excerpts followed by my ‘fourth grade version’ and interpretation. This should help you get to the bottom line on how and why this can significantly help you in your quest to lose weight naturally and improve your health.

Deal? Here we go…

The science says: In June of 2009, the medical journal, Molecular and Cellular Biology stated that:  neuronal PTP1B inhibition results in decreased hypothalamic AMPK activity, isoform-specific AMPK activation in peripheral tissues and downstream gene expression changes that promote leanness and increased energy expenditure. Therefore, the mechanism by which PTP1B regulates adiposity and leptin sensitivity is likely to involve coordinated regulation of AMPK in hypothalamus and peripheral tissues.

The interpretation: Inhibiting PTP1B may actually have an effect on the brain that would help you improve body composition and burn fat.

The science says: PTP1B Inhibitors:  (PTP1B) is a highly validated molecular target, which mediates insulin resistance in mammals. PTP1B dephosphorylates the insulin receptor (IR) thus blunting its ability to transduce signal upon insulin binding. Inhibitors of PTP1B would be expected to restore activity to the IR and thus would find therapeutic benefit in the treatment of diabetes.

The interpretation: Discovering and manufacturing PTP1B inhibitors are currently one of the ‘hot topics’ in the pharmacological approach to to finding a drug to address the obesity problem, which is a primary contributing factor to type 2 diabetes.

The science says: Protein tyrosine phosphatase 1B (PTP1B) contributes to leptin resistance by inhibiting intracellular leptin receptor signaling. Hypothalamic PTP1B is specifically increased during HF diet-induced leptin resistance. This increase in PTP1B is due in part to chronic hyperleptinemia, suggesting that hyperleptinemia is one mechanism contributing to the development of leptin resistance.

The interpretation: When mice are fed a high fat diet it can increase the amount of PTP1B in the brain. A high fat diet possibly induced an overabundance of circulating leptin which leaves more leptin in the blood. The body then may become resistance to leptin’s effects; two of which are  regulating appetite and burning fat.

The science says: Neuronal PTP1B regulates adiposity, body weight and leptin action.

The interpretation: PTP1B has a big say in whether you store excess fat, how much you weigh and it also plays a pivotal role in the function of one of your master metabolic hormones-leptin.

The science says: PTP1B is expressed in hypothalamic regions harboring leptin-responsive neurons. PTP1B regulates leptin signaling in vivo, likely by targeting Jak2. Mice lacking the protein-tyrosine phosphatase PTP1B are hypersensitive to insulin and resistant to obesity. PTP1B may be a novel target to treat leptin resistance in obesity.

The interpretation: PTP1B is present within the brain and effects the way that leptin is able to effect the brain. Mice that were devoid of PTP1B were literally resistant to obesity. One could extrapolate that with either the absence or decreased over-expression of PTP1B, leptin and insulin would both work more efficiently to regulate weight and metabolism. This study showed that PTP1B does in fact regulate leptin signaling.

The science says: Protein tyrosine phosphatase 1B (PTP1B) is a key negative regulator of signaling by both of these hormones, so that inhibitors of this enzyme may provide promise for correcting endocrine abnormalities in both diabetes and obesity. As with other tyrosine phosphatases, identification of viable drug candidates targeting PTP1B has been elusive because of the nature of its active site. Beginning with novel phosphotyrosine mimetics, we have designed some of the most potent PTP1B inhibitors. However, their highly acidic structures limit intrinsic permeability and pharmacokinetics.

The interpretation: “We wish we could find something that inhibits PTP1B without so many side effects because if we could, we would make billions.”

As far back as 2002 analysts have estimated that an effective and safe drug targeting obesity could generate as much as $26 billion per year in the USA alone. “It is probably the largest pharmaceutical market ever, and carries with it 27–30 dangerous co-morbidities,” said Louis Tartaglia, vice president of metabolic diseases at Millennium Pharmaceuticals. If you add the patients who are obese and diabetic, the number soars even higher, as obesity and diabetes are linked diseases. (Some research says that as much as 80% of type 2 diabetes is related to obesity.

The science says: Published studies demonstrate that the botanically derived phytochemical, isolated and purified single-peak Isoquinoline Alkaloid Berberine HCl, specifically and potently inhibits human Protein Tyrosine Phosphates 1B (PTP1 B).

The interpretation: LepToThin™ with LeptoPro™ was formulated to specifically and naturally improve the body’s ability to respond to leptin signaling, thus helping you become better able to lose weight.

References:

LepToThin review

Am J Physiol Endocrinol Metab 296: E291-E299, 2009

Nature Medicine – 12, 917 – 924 (2006)

Dev Cell. 2002 Apr;2(4):385-7.

Well, for the record, the scientifically accurate answer is…compositionally, LeptiPro™ is a purified API-grade Berberine in the stable HCl form, conjugated and complexed with a proprietary Long-Chain Fatty Acid matrix for enhanced uptake and transport across the blood-brain-barrier.

Whew! Now here’s the good part….

There is mounting evidence that the clinical efficacy of purified API-grade Berberine shows potent and specific inhibition of PTP1B, among other important mechanisms dealing  with weight loss, weight control, and the hormones that influence those functions.

In layman’s terms…it just may be science’s newest answer to your weight loss prayers!

LepToThin™ is the first product available to include the powerful natural compound LeptiPro™.  And if you have been unable to lose weight, this might just be your “knight in shining armor!”

What is exciting is that LeptiPro was developed as a natural and efficacious way to help modulate weight via multiple mechanisms, meaning it works on a variety of physiological pathways– including, but not limited to:

1) The enhancement of leptin sensitivity (primarily via potent and specific inhibition of Protein Tyrosine Phosphatase 1B — PTP1B). Over ten years of science is now pointing to the fact that this may be a key factor in the chronically overweight and obese.

2) The enhancement of insulin sensitivity (via multiple mechanisms, including up-regulation of AMP-activated Protein Kinase (AMPK), up-regulation of AMP/ATP ratios, down-regulation of Interleukin-6 (IL-6), inhibition of alpha-Glucoside, and inhibition of PTB1B. (Insulin and leptin work hand-in-hand.)

3) The down-regulation of lipogenesis and up-regulation of energy expenditure in adipose tissue, decreasing fat production and fat storage and increasing fat burning.

4) The down-regulation of adipogenic enzymes and transcription factors.

What does this mean for you? Well, for most people it is THE scientific breakthrough you’ve been waiting for in terms of breaking through stubborn barriers that have kept you from losing weight in the past.

You see, LeptiPro™ helps your body conquer the two ‘villains’ of weight management…cravings and fat storage.

And because LeptiPro is  shown to have powerful positive effects on balancing the hormone that controls those two ‘villains,’ most people experience unprecedented weight loss because these problems have never been effectively addressed.

LepToThin’s  proprietary matrix capitalizes on these powerful mechanisms and adds to it the potent fat burning and anti-inflammatory effects of EGCG’s in our green tea extract. Also included is a patented  form of  chromium, which is shown to have blood sugar balancing properties. Added with this is energy enhancing panax ginseng. To top it all off…a promising new ‘superfood’ from the sea, known as fucoxanthin, may potentially work very well in assisting you with losing weight.

For more information about LepToThin go here.  LepToThin review.

“HORMONES!”

If you’ve ever had cravings that you just can’t keep under control, this new science is going to blow your mind. At the same time it will  give you the biggest sense of self satisfaction you’ve ever experienced because you’ll finally understand why.

Ladies and gentlemen, how powerful are hormones?

I know from being married and having a pregnant wife that they’re more powerful than a tornado, hurricane, flood, and thunder and lightening all mixed together.

So I  R-E-S-P-E-C-T them.

One common misconception about overweight or obese people is that they could lose weight if they really wanted to.

In the words of Lee Corso…

“Not so fast my friend!”

New studies show that gaining a lot of weight and then trying to take it back off is far more complex than simply not being able to control yourself, or being lazy or weak.

The process of gaining weight is just that, a process. There are hundreds and thousands of neurochemically mediated synapses that go a bit haywire.

There are ‘checks and balance’ systems in the body that get toppled. Organs and cells start struggling just to deal with the excess stress.

This is, in part, the start of many disease processes.

So I get a little defensive when the ‘gurus’ start blaming people for not eating right and exercising enough.

We all should, by now, understand the amazing life giving properties and benefits of exercising and eating right. But the fact is we don’t. There is no perfect diet and there is no perfect exercise program.

Thankfully, we are all unique.

And although I love nutritional science and practice orthomolecular medicine and I respect exercise physiology. The absolute truth is, when you are dealing with humans, there are no absolutes.

Why?

Each one of us is a different combination of quantum energy. (Don’t get scared by the big metaphysical word, I’m done.)

For example, I might drink a few beers and want to reminisce and hug all over you. The guy next to me might have a few and want to brawl.

Same beers…but two different chemical bodies that they were poured in to.

In science, if you mix A with B in equal parts, every time you will get C. That’s reproducible science. Whenever humans are involved, you don’t know what B is, exactly.

So here’s my point- let me ask the ‘majority’ of people who have struggled with weight this one very important question in regards to eating right and exercising…

“How’s that worked out for ya?”

What some of you may be very surprised to hear is that a lot of people will answer, “Not very well!”

You see for many people, losing weight has been a futile battle to fight powerful hormonal responses in the body gone awry. Even those with the best intentions were set up for failure to start with.

These processes are why willpower alone won’t take the weight off. And they are a big reason why people can’t ‘stick’ to diets or exercise routines.

Before I go on, let me fervently say that I am the biggest exercise and nutrition advocate around. Don’t misconstrue this into thinking that I discount those vital health needs.

So… if you are one of those people who can’t stick to a diet or if you have taken weight off and it comes right back on, I’m going to share some facts with you that you may have never heard. Basically, your weight problem is a hormone imbalance.

The Master “Fat Burning Hormone”

The way that we either burn calories for energy or store them as fat, is largely determined by a balance of hormones in our bodies. With a sub-par diet, too much stress, and not enough rest, our hormones can get out of balance.

The hormone leptin is primarily responsible for the regulation of metabolism and weight by decreasing hunger and food consumption, as well as being responsible for utilizing fat for energy.

How important are these functions in determining whether you can or can’t lose weight?

If leptin is prevented from doing its job in the body, the chemical signals to tell you to stop eating never reach the brain. Instead, the body is signaled that more calories are needed. Therein lies the problem…

“Willpower Is No Match For Hormones”

People wonder why willpower alone won’t take the weight off. Willpower is no match for the brain’s hormonal signals that are telling you that you need more food.

Even the toughest among you can sustain it for only so long. And then what happens? I think you know… you’re right back to where you started.

Research shows that most people struggling with weight problems have high blood leptin levels. You may say to yourself, “If  leptin is so powerful and it burns fat and controls cravings how could I have high levels?”

It’s called leptin resistance. It’s very similar to insulin resistance…and most overweight people suffer from it and don’t even know it. It is extremely common.

Leptin is prevented from getting into the brain where it needs to  signal the body to

1) Stop eating and 2) Burn fat.

Without leptin working in the brain, it is all but impossible to regulate appetite, metabolism and weight, and that, my friend, is why willpower alone may have fallen short.

So with bookstore shelves devoting entire sections to diet and exercise, you would think America would have all the tools necessary to be in tip top shape, yet statistics on obesity and being overweight continue to rise.

How big of a problem is this ‘leptin resistance’ thing?

HUGE!

“I believe that the discovery of leptin resistance is the key to freeing millions of overweight Americans from the tyranny of yo-yo dieting, food cravings and a continual struggle with their weight.”

Leo Galland, M.D.,
Author, “The Fat Resistance Diet”

In fact, many studies are pointing to the fact that insulin resistance happens because of leptin resistance. More studies need to be done, but the new science shows that the hormones insulin and leptin are literally intertwined in terms of their function.

Fact: 80% of all type II diabetics are overweight. Coincidence? I think not, as is backed by the newest research.

Hmmmm…where do we go from here?

Brand New Science Gives Promise

Leptin resistance occurs, in part, when a protein in the body, called PTP1 B, interferes with leptin’s ability to cross into the hypothalamus of the brain and do its thing, burn fat, stop cravings.

Science and big pharma companies have been trying to isolate a way to potently ‘block’ PTP1B, in order to restore the powerful fat burning effects of leptin.

Why?

Because it’s the NEXT BIG THING.

One of the most respected naturally minded doctors in the world, Dr. Joseph Mercola, owner of the worlds most popular natural health newsletter and website recently said that,

“Several pharmaceutical companies are already busy at work trying to identify drugs that would make good candidates for inhibition of PTP1B in people.”

Why?

Because it’s the next big thing; 0besity, huge (sorry for the pun), diabetes, huge, a nation overweight and getting worse…huge! When it comes to the research and development of leptin and insulin sensitizers, there aren’t too many things  bigger right now that medical and pharmaceutical research is trending towards.

If they could find an answer to this problem, it would be…you guessed it…huge. It’s probably safe to say that this could be the biggest breakthrough in weight loss science in the past 20 years.

In the labs right now, scientists have been able to block PTP1B in mice and guess what? There is a huge decease in overall body fat and as much as an 80% increased capability for the them to be resensitized to insulin and leptin. And boys and girls, those are THE two master hormones for controlling your weight and metabolism.

But, here’s the kicker… even when the mice were fed high fat diets, they still didn’t gain weight.  Are you with me, so far?

I think you may be starting to see why this just may be the new ‘holy grail’ of weight loss science.

So why am I so excited?

Eureka… We’ve Done It!

The best thing is it’s an all-natural plant based compound!

It is a berberine formulation that has been specifically and proprietarily bound to fatty acids. The body can actually use it to increase leptin signaling and restore fat burning and decrease false and unnecessary hunger cravings.

Currently there is only one clinically validated compound that can potently block PTP1 B levels, thus reestablishing normal leptin signaling by actually crossing the blood brain barrier and addressing the malfunction at its source.

It’s called LeptiPro™ and it’s in a proprietary formula called LepToThin™.

LeptiPro™ has been clinically proven to restore normal leptin signaling by blocking PTP1B, thereby, naturally balancing and resensitzing  the signaling of your fat burning and hunger commanding hormones in the body.

So it now allows leptin to flow to the brain and signal the body to stop eating and burn excess fat.

How’s that for an answer to your prayers?

This is the pinnacle of leptin re-sensitizing thus far in the medical community. People who have tried LepToThin™ with LeptiPro™ say,

“It’s the most powerful appetite suppressant I’ve ever experienced.”

Those who have failed with diet after diet, only to put on the pounds again, are experiencing reductions in weight that they have never experienced before in their adult lives.

Why?

Because it works directly on the brain. And it’s all natural, with virtually no side effects as you may expect with drugs.

It’s been called ‘the anti-diet’ pill because it has no harmful effects or jittery effects on the body like a typical diet pill.

While it’s obviously important to eat a healthy diet when you are trying to lose weight, it takes more willpower than you can muster to avoid sugary snacks if you are leptin resistant.

By addressing leptin resistance and restoring balance to the body, you’ll have your hormones working FOR you and not fighting thousands of years of physiological history with sheer willpower!

So, if you’ve struggled with your self image regarding your weight or if your self confidence took a hit because of your failure with ‘dieting’… you can take a big breath and realize that it wasn’t all your fault.

Now, when you get the weight off, come back here for guidance on exercise and a leptin enhancing, anti-inflammatory diet so you can keep it off for good!

You have suffered enough and you wouldn’t want to have to learn that lesson again.

Oh, by the way, when you do get to your ideal weight, the LepToThin™ formula will help you to keep it off as well.

LepToThin™ with LeptiPro™ has set a new standard in weight loss science. If you’re interested, you can order it here starting March 30, 2009.

View the Press Release Here

References:

Anonymous. Fat and free will. Nature Neuroscience. 2000;3(11):1057.

Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF. Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans. The New England Journal of Medicine. 1996;334(5):292-295.

Martin SS, Qasim A, Reilly MP. Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease. Journal of the American College of Cardiology. 2008;52(15):1201-10.

Nature.com September 2002 Protein PTB1B Inhibitors For Diabetes

Here’s the skinny…

Most overweight people want to lose weight to protect their health. Restricting calories and following a diet avoiding certain foods, is the most common weight loss method. Although eating healthy is important for losing weight and getting a healthy body, diets rarely provide long term success.

Most people lose weight on a diet, but they quickly gain it back once they stop dieting. Hence the term ‘yo-yo’ dieting.

This frustrating result usually leads to a new diet with the same process happening over and over again. Since most people’s weight goes up and down like a yo-yo, with all these repeated diets, this occurrence has actually been called the yo-yo diet syndrome.

Yo-yo dieting is not only frustrating and discouraging for the dieter, but it puts an additional strain on a body that is already dealing with imbalances and inflammation due to being overweight. It is important to realize that the yo-yo diet syndrome loss is a very common problem and that trying different diets are seldom the solution.

Current research shows that no matter how diligently you stick to a diet, it will only ever be a temporary fix until you address what is causing the weight gain—usually a hormonal imbalance.

Hormones work in the gut and the brain to signal the body when to eat and when to stop eating. They also control whether calories are used for energy or stored as fat, thereby regulating metabolism. In particular, the hormone, leptin, is important in the control of these functions, like the feeling of being full after eating.

Fructose is found in the majority of foods in the typical American diet, even in the seemingly healthy ones such as breads, cereals, pasta sauce, salad dressings, granola bars and ketchup that are a part of many diets.

Research shows that consuming too much fructose leads to an inability for leptin to get into the brain where it needs to work. It is as if you get to work and the door is locked and you have no key. You cannot possibly get your work done standing outside the door!

Similarly, leptin cannot produce signals to tell the body to stop eating or to quicken the metabolism. Dieting, then, only works for a while but is not a permanent fix, just like putting a bandage on a gunshot wound may stop blood from pouring out but does not help to heal it.

Essentially, what studies show is that you need to get your leptin back into the brain where it can work to help you lose weight and keeping it off long term. The supplement LepToThin™ with LeptiPro™ was designed specifically to deal with this problem.

References:

Shapiro A, Mu W, Roncal C, Cheng KY, Johnson RJ, Scarpace PJ. Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding. Am J Physiol Regul Integr Comp Physiol. 2008;295(5):R1370-5.

Wadden TA, Considine RV, Foster GD, Anderson DA, Sarwer DB, Caro JS. Short- and Long-Term Changes in Serum Leptin in Dieting Obese Women: Effects of Caloric

Restriction and Weight Loss. The Journal of Clinical Endocrinology & Metabolism. 1998;83(1):214-218.

Weigle DS, Duell PB, Connor WE, Steiner RA, Soules MR, Kuijper JL. Effect of Fasting, Refeeding, and Dietary Fat Restriction on Plasma Leptin Levels. The Journal of Clinical Endocrinology & Metabolism. 1997;82(2):561-565.

Ask anyone well-versed in human biochemistry how to lose rolls of belly fat and you’ll hear one primary answer: shift the body’s biochemical and metabolic pathways to burn fat and you’ll lose weight every single time!

You don’t have to know a lot about biochemistry to understand that there are metabolic pathways that burn fat and metabolic pathways that store fat.

If you take certain actions, you can shift your body’s metabolic pathways to burn fat. Likewise, if you take certain actions, you can shift your body’s metabolic pathways to store fat. For example, if you begin exercising, you shift your pathways to burn fat. If you eat foods high in sugar, your pancreas will release a large burst of insulin that will shift your body to the pathways that store fat.

One of the newest phytochemicals that helps the body shift to fat-burning metabolic pathways is the isoquinoline alkaloid berberine HCl. Berberine HCl, found exclusively in LeptiPro.™ And LeptiPro.™ is currently only available as part of The CleanseToThin™ Weight Loss System.

It shifts the body’s metabolic pathways to burn fat by:
• Down regulating the production of fat-building enzymes. (The less fat building enzymes you have, the greater  possibility for losing stomach fat.)
• Down regulating the process of fat building in the body. (This process is called lipogenesis and when it is down regulated, it’s essentially shut down. It’s as if the train track that leads to fat-building is simply out of service.)
• Enhancing glucose metabolism
• Improving glucose tolerance
• Up regulating energy expenditure called thermogenesis in fat cells. This means that it will step up fat burning.

Using CleanseToThin™ with LeptiPro™ could be the most intelligent way to lose stomach fat.