A significant amount of the newest science and research attempting to tackle America’s growing obesity problem is focused on hormonal disruptions and imbalances such as leptin resistance. LepToThin™ is natural science’s newest answer, in supplement form, to help address this issue. LepToThin™ contains LeptiPro™ which is the primary active ingredient to assist in improving leptin signaling. The main mechanism of action of this supplement occurs by inhibiting protein tyrosine phosphatase 1B, commonly known as (PTP1B). A plethora of research is currently being performed to assess the efficacy of PTP1B in the treatment of obesity, insulin resistance and leptin resistance.

To help your understanding of this ever-important concept and physiological cascade of events, I’ll provide a number of credible research excerpts followed by my ‘fourth grade version’ and interpretation. This should help you get to the bottom line on how and why this can significantly help you in your quest to lose weight naturally and improve your health.

Deal? Here we go…

The science says: In June of 2009, the medical journal, Molecular and Cellular Biology stated that:  neuronal PTP1B inhibition results in decreased hypothalamic AMPK activity, isoform-specific AMPK activation in peripheral tissues and downstream gene expression changes that promote leanness and increased energy expenditure. Therefore, the mechanism by which PTP1B regulates adiposity and leptin sensitivity is likely to involve coordinated regulation of AMPK in hypothalamus and peripheral tissues.

The interpretation: Inhibiting PTP1B may actually have an effect on the brain that would help you improve body composition and burn fat.

The science says: PTP1B Inhibitors:  (PTP1B) is a highly validated molecular target, which mediates insulin resistance in mammals. PTP1B dephosphorylates the insulin receptor (IR) thus blunting its ability to transduce signal upon insulin binding. Inhibitors of PTP1B would be expected to restore activity to the IR and thus would find therapeutic benefit in the treatment of diabetes.

The interpretation: Discovering and manufacturing PTP1B inhibitors are currently one of the ‘hot topics’ in the pharmacological approach to to finding a drug to address the obesity problem, which is a primary contributing factor to type 2 diabetes.

The science says: Protein tyrosine phosphatase 1B (PTP1B) contributes to leptin resistance by inhibiting intracellular leptin receptor signaling. Hypothalamic PTP1B is specifically increased during HF diet-induced leptin resistance. This increase in PTP1B is due in part to chronic hyperleptinemia, suggesting that hyperleptinemia is one mechanism contributing to the development of leptin resistance.

The interpretation: When mice are fed a high fat diet it can increase the amount of PTP1B in the brain. A high fat diet possibly induced an overabundance of circulating leptin which leaves more leptin in the blood. The body then may become resistance to leptin’s effects; two of which are  regulating appetite and burning fat.

The science says: Neuronal PTP1B regulates adiposity, body weight and leptin action.

The interpretation: PTP1B has a big say in whether you store excess fat, how much you weigh and it also plays a pivotal role in the function of one of your master metabolic hormones-leptin.

The science says: PTP1B is expressed in hypothalamic regions harboring leptin-responsive neurons. PTP1B regulates leptin signaling in vivo, likely by targeting Jak2. Mice lacking the protein-tyrosine phosphatase PTP1B are hypersensitive to insulin and resistant to obesity. PTP1B may be a novel target to treat leptin resistance in obesity.

The interpretation: PTP1B is present within the brain and effects the way that leptin is able to effect the brain. Mice that were devoid of PTP1B were literally resistant to obesity. One could extrapolate that with either the absence or decreased over-expression of PTP1B, leptin and insulin would both work more efficiently to regulate weight and metabolism. This study showed that PTP1B does in fact regulate leptin signaling.

The science says: Protein tyrosine phosphatase 1B (PTP1B) is a key negative regulator of signaling by both of these hormones, so that inhibitors of this enzyme may provide promise for correcting endocrine abnormalities in both diabetes and obesity. As with other tyrosine phosphatases, identification of viable drug candidates targeting PTP1B has been elusive because of the nature of its active site. Beginning with novel phosphotyrosine mimetics, we have designed some of the most potent PTP1B inhibitors. However, their highly acidic structures limit intrinsic permeability and pharmacokinetics.

The interpretation: “We wish we could find something that inhibits PTP1B without so many side effects because if we could, we would make billions.”

As far back as 2002 analysts have estimated that an effective and safe drug targeting obesity could generate as much as $26 billion per year in the USA alone. “It is probably the largest pharmaceutical market ever, and carries with it 27–30 dangerous co-morbidities,” said Louis Tartaglia, vice president of metabolic diseases at Millennium Pharmaceuticals. If you add the patients who are obese and diabetic, the number soars even higher, as obesity and diabetes are linked diseases. (Some research says that as much as 80% of type 2 diabetes is related to obesity.

The science says: Published studies demonstrate that the botanically derived phytochemical, isolated and purified single-peak Isoquinoline Alkaloid Berberine HCl, specifically and potently inhibits human Protein Tyrosine Phosphates 1B (PTP1 B).

The interpretation: LepToThin™ with LeptoPro™ was formulated to specifically and naturally improve the body’s ability to respond to leptin signaling, thus helping you become better able to lose weight.

References:

LepToThin review

Am J Physiol Endocrinol Metab 296: E291-E299, 2009

Nature Medicine – 12, 917 – 924 (2006)

Dev Cell. 2002 Apr;2(4):385-7.

Doh…Thank God, there is.

On Oprah’s most recent show, Dr. Oz explains a new experimental weight loss surgery that basically consists of cutting holes in the skull and then inserting probes into the brain, to control the area of the brain responsible for hunger and cravings. Next, ‘regulating devices,’ similar to pacemakers, are  implanted into the patients chest. The doctors say the implants monitor electrical currents that control  food cravings and feelings of fullness or satisfaction.

The patient featured on Oprah’s show, who recently underwent this new procedure, is only the second person ever to have it done.

Her plight is very familiar to most chronically overweight and obese people. “I’ve tried everything else,” she says.  She’s tried dieting, exercising, even stomach stapling and gastric bypass surgery in an attempt to reach a healthy weight…but nothing has worked. An all too familiar story, unfortunately.

If you read the article, the surgeon who performed the surgery, Dr. Don Whiting talked about how they go into the brain, “We’re actually going to the control center, we think, to adjust things in a different way.”

WE THINK???

Back to the patient…

“I really believe that it’s got something to do with the brain,” she says.

Now……..the first thing I thought of when I heard her statement was, “Was this an original idea from her or was it suggested to her?”

Just a thought.

I’ve helped  a lot of weight loss patients and can’t remember anyone saying, “I think it has something to do with my brain.”

BUT…she may be right…

Shes goes on to say, “I’ve always known in my heart that there had to be something else.” This is a very familiar statement to me. Usually it arises after numerous, diets, exercise programs, weight loss supplements, and prescription diet pills that simply do not work for that individual.

Many people are exhaustively told, “just eat less and exercise more.”

And although that statement is true in principle, will power alone will not overcome a hormonally imbalanced body. For those of you who don’t have a weight problem this may sound contrary but just eating less and exercising more may be savvy advice that is set up to fail for that person. Especially if the brain isn’t receiving and sending the proper hormonal signals.

I’ve seen countless people try to do ‘what’s right’ yet still lose the war with being overweight. So this patient may be dead-on correct when she says, ‘there has to be something else.’ There’s got to be a better way. Brain surgery for weight loss? I’m opened minded but what’s next… decapitation for headaches?

The proponents to this new ‘surgical solution’ optimistically suggest, “what if there was a medical solution that could put an end to  yo-yo dieting, food cravings and calorie counting.”  Valid question, right?

Dr. Oz declared on the show, “If you put a probe in there and put electricity through it, you can stimulate that part of the brain so you no longer get hungry.”

The brain does, in fact, have a region of the brain, the hypothalamus, that links the nervous system to the endocrine system and has a big ‘say-so’ in whether your body craves food or not.

But, what if you could accomplish the same exact thing that this new scientific breakthrough brain surgery does and save yourself a few holes in your head?

Since Oprah was the first to break this story, let me be the second to break the really exciting news about the brain and significant weight loss when all else has failed.

Introducing….

“The Brain Surgery Alternative To Effectively Controlling Hunger and Obtaining Safe and Significant Weight Loss…. Through the Brain….Without a Drill”

The tool is not a drill… but a hormone. Leptin.

Leptin is a recently discovered hormone that directs signaling to the brain to control eating and induce satiety (sense of fullness). This protein hormone Leptin is encoded by the obesity (ob) gene.  And in the last several years it has  repeatedly been identified in published research as one of the primary modulators of body weight and metabolism. Sounds like a miracle drug, right?

But that’s not all. Leptin also disposes of cellular fat by up-regulating thermogenesis (fat burning) and metabolic rate. Once leptin reaches the brain (in the hypothalamus) it mediates weight loss by decreasing hunger and food consumption, and increasing energy expenditure, which then results in a loss of adipose or fat tissue mass and an increase in lean muscle mass.

And isn’t that what we are all so heatedly pursuing? Now, here’s the bad news…

Clinical findings show that the vast majority of overweight people have elevated levels of leptin due to “leptin resistance.” So although leptin sounds like a ‘miracle,’ if the brain becomes resistant to its signals, those powers are all for nothing.

When brain levels of leptin are low due to “leptin resistance” – even if there are high circulating blood levels of leptin – food cravings and weight gain occur because the body believes that it is hungry and goes into a state of continued fat storage.

AH HA!

Isn’t that the plight of this patient who had experimental brain surgery? Remember…she tried exercising, she tried dieting, she even had other forms of surgery… all to no avail?

Let’s revisit this science again…

When leptin cannot reach the brain, because it cannot cross the blood brain barrier,

“food cravings and weight gain occur because the body believes it is hungry and goes into a state of continuous fat storage!”

Leptin acts within the brain’s hypothalamic centers once it crosses the blood brain barrier. But in “leptin resistance,” it can’t effectively get to that part of the brain to perform its “weight management magic.” But here is the groundbreaking science that gives people like this, hope.

Recent studies have shown that an increase of a certain protein, Protein Tyrosine Phosphatase 1 b, or (PTP1B), is the key to unlocking the door to let leptin reach the centers in the brain that not only control hunger but burn fat!

By reversing “leptin resistance,” through the blocking of PTP1 B, the function of the protein hormone leptin is restored so that the hypothalamic center can normally and effectively modulate body weight and metabolism.

And it can be done naturally, if you know what I’m about to tell you. It’s a mouthful but it may be THE KEY to possibly unlocking the secrets of true weight loss and management like nothing before.

Here is the key…..published studies demonstrate that the all-natural, botanically derived phytochemical,  Isoquinoline Alkaloid Berberine, specifically and potently inhibits human Protein Tyrosine Phosphatase 1B (PTP1 B).

What does this mean to you? It’s the key to unprecedented weight loss and maybe an appearance on Oprah!

Yes, this is brand new.

Yes, this is cutting edge.

Yes, it’s like rocket science… but it’s not brain surgery. Somebody please tell Oprah.

There is currently one place in the world to get this ‘key’ to unlock your body’s inherent ability to lose weight….www.GoGetThin.com

Here’s the skinny…

Most overweight people want to lose weight to protect their health. Restricting calories and following a diet avoiding certain foods, is the most common weight loss method. Although eating healthy is important for losing weight and getting a healthy body, diets rarely provide long term success.

Most people lose weight on a diet, but they quickly gain it back once they stop dieting. Hence the term ‘yo-yo’ dieting.

This frustrating result usually leads to a new diet with the same process happening over and over again. Since most people’s weight goes up and down like a yo-yo, with all these repeated diets, this occurrence has actually been called the yo-yo diet syndrome.

Yo-yo dieting is not only frustrating and discouraging for the dieter, but it puts an additional strain on a body that is already dealing with imbalances and inflammation due to being overweight. It is important to realize that the yo-yo diet syndrome loss is a very common problem and that trying different diets are seldom the solution.

Current research shows that no matter how diligently you stick to a diet, it will only ever be a temporary fix until you address what is causing the weight gain—usually a hormonal imbalance.

Hormones work in the gut and the brain to signal the body when to eat and when to stop eating. They also control whether calories are used for energy or stored as fat, thereby regulating metabolism. In particular, the hormone, leptin, is important in the control of these functions, like the feeling of being full after eating.

Fructose is found in the majority of foods in the typical American diet, even in the seemingly healthy ones such as breads, cereals, pasta sauce, salad dressings, granola bars and ketchup that are a part of many diets.

Research shows that consuming too much fructose leads to an inability for leptin to get into the brain where it needs to work. It is as if you get to work and the door is locked and you have no key. You cannot possibly get your work done standing outside the door!

Similarly, leptin cannot produce signals to tell the body to stop eating or to quicken the metabolism. Dieting, then, only works for a while but is not a permanent fix, just like putting a bandage on a gunshot wound may stop blood from pouring out but does not help to heal it.

Essentially, what studies show is that you need to get your leptin back into the brain where it can work to help you lose weight and keeping it off long term. The supplement LepToThin™ with LeptiPro™ was designed specifically to deal with this problem.

References:

Shapiro A, Mu W, Roncal C, Cheng KY, Johnson RJ, Scarpace PJ. Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding. Am J Physiol Regul Integr Comp Physiol. 2008;295(5):R1370-5.

Wadden TA, Considine RV, Foster GD, Anderson DA, Sarwer DB, Caro JS. Short- and Long-Term Changes in Serum Leptin in Dieting Obese Women: Effects of Caloric

Restriction and Weight Loss. The Journal of Clinical Endocrinology & Metabolism. 1998;83(1):214-218.

Weigle DS, Duell PB, Connor WE, Steiner RA, Soules MR, Kuijper JL. Effect of Fasting, Refeeding, and Dietary Fat Restriction on Plasma Leptin Levels. The Journal of Clinical Endocrinology & Metabolism. 1997;82(2):561-565.

The answer may be low levels of the hormone called leptin. The hormone heads straight for the body’s satiety and hunger center located in the hypothalamus and turns on your ability to burn more calories through thermogenesis. But that’s not all it does. Leptin also increases your metabolic rate, resetting it to where it should be.

Researchers have found that it’s possible to have high levels of leptin in the blood, but the body can fail to transport it to the brain. This is called “leptin resistance.” When the brain doesn’t get the leptin it needs, then food cravings and weight gain occur and it feels as if we don’t have any willpower.

However, it’s not a matter of willpower or not. It’s a matter of either there’s enough leptin in the brain, or there’s not. Without the leptin in the brain, the body thinks it is hungry and hoards calories.

The good news is that leptin resistance can be reversed. By far the most promising substance to help combat the effects of leptin resistance is called Isoquinolone Alkaloid berberine, found exclusively in LepToThin™.